TOM7 — Neurospora crassa

Summary

NCU04181 (TOM7) in Neurospora crassa encodes a structural component of the mitochondrial outer membrane translocase (TOM) complex, with annotated structural molecule activity and ATP hydrolase activity. The gene is associated with mitochondrial outer membrane protein import, mitochondrial matrix protein import, and mitochondrion distribution. TOM7 localises to the mitochondrial outer membrane, the TOM complex, and the ER. Phenotypic associations link the gene to abnormal mitochondrial distribution, absent or decreased respiratory metabolism, absent spore germination, arrested vegetative growth, decreased mitophagy, increased sporulation efficiency, and abnormal cell cycle progression in G1 phase. Additional associations include abnormal peroxisomal morphology, increased chitin deposition, and decreased mitochondrial genome maintenance. Studies of related genes in other species connect the TOM7 family to mitochondrial protein import and outer membrane biogenesis.