ARP1 — Neurospora crassa

Summary

NCU04247 (ARP1, ro-4) in Neurospora crassa encodes a structural constituent of the cytoskeleton with ATP-binding and hydrolase activity, belonging to the actin/actin-like and ATPase NBD domain families. The gene is associated with nuclear movement, double-strand break repair, and vesicle transport, and its product localises to the dynactin complex, actin cytoskeleton, hyphal tip, and sites of polarized growth. Phenotypic associations include abnormal lifespan, decreased cell fusion, absent filamentous growth, abnormal nuclear transport and chromosome segregation, increased mutation frequency, and decreased growth in exponential phase. The gene is also linked to abnormal septum formation, chitin deposition, and mating projection morphology, as well as delayed or arrested cell cycle progression in M phase. Studies of related genes in other species connect the family to respiratory growth and acid sensitivity.