aroM — Neurospora crassa

Summary

NCU04298 (aroM) on Neurospora crassa chromosome 5 encodes the pentafunctional AROM polypeptide. The gene is annotated with 3-dehydroquinate synthase activity, 3-phosphoshikimate 1-carboxyvinyltransferase activity, shikimate kinase activity, shikimate 3-dehydrogenase (NADP+) activity, 3-dehydroquinate dehydratase activity, ATP binding, and metal binding. It is associated with aromatic amino acid family biosynthesis, the shikimate pathway, amino acid biosynthesis, digestion, proteolysis, and NO storage. The product localises to the cytoplasm. A related gene, aroM-2, is present in the genome. Related genes in other species, including Fusarium and Verticillium species, link the family to the same core shikimate pathway enzymes (EC 2.7.1.71, 4.2.3.4, 1.1.1.25, 2.5.1.19, 4.2.1.10).