CHS7 — Neurospora crassa

Summary

NCU04350 (CHS7) on Neurospora crassa chromosome 4 encodes a chitin synthase A with chitin synthase activity (EC 2.4.1.16), cytoskeletal motor activity, actin binding, and ATP binding. The protein contains chitin synthase, myosin head motor, DEK_C, cytochrome b5-like heme/steroid-binding, nucleotide-diphosphosugar transferase, and P-loop NTPase domains. CHS7 is associated with chitin anabolism, ascospore formation, and fungal-type cell wall organization. It localizes to the myosin complex, cytoplasmic vesicle membrane, cross wall, cell periphery, cell tip, and plasma membrane. Related genes in other species are linked to polysaccharide content, turgor pressure, loss of pathogenicity, and reduced virulence.