IRC5 — Neurospora crassa

Summary

NCU04445 (IRC5, also known as NcIRC5 or NcINO80) on Neurospora crassa chromosome 4 encodes a protein with SNF2/RAD54-like helicase domains, including ATP-binding and zinc-binding motifs, and exhibits ATP-dependent protein-DNA complex displacement, helicase, and ubiquitin ligase activities. The gene is associated with chromatin organization and remodeling, DNA repair pathways such as homologous recombination, nucleotide excision repair, and replication fork reversal, as well as error-free post-replication repair and bypass DNA synthesis. It localizes to the nucleus, chromatin, and sites of double-strand breaks. Phenotypic associations link IRC5 to cell cycle progression, particularly G1/S phase transition, chromosome segregation, meiotic recombination, mutation frequency, transposable element transposition, and replicative lifespan. Related genes in other species connect this gene to broader chromatin regulatory complexes.