FRH — Neurospora crassa

Summary

NCU04472 (FRH) on Neurospora crassa chromosome 4 encodes a DEAD/DEAH box helicase with DNA helicase activity, RNA helicase activity, helicase activity, nucleic acid binding, RNA binding, ATP binding, ATP hydrolase activity, and hydrolase activity. The protein belongs to the SKI2 subfamily of helicases and is associated with the Ski complex, TRAMP complex, and NURS complex, localizing to the nucleus, nucleolus, cytoplasm, cytosol, nuclear body, and heterochromatin islands. FRH is linked to circadian rhythm, rhythmic process, RNA surveillance, polyadenylation-dependent ncRNA catabolic process, siRNA catabolic process, nuclear mRNA surveillance of spliceosomal pre-mRNA splicing, non-stop decay, 3'-5' NMD, heterochromatin island assembly, degradation of meiosis-specific transcripts, sno(s)RNA processing, maturation of 5.8S rRNA, resolution of meiotic recombination intermediates, flocculation, cellular localization, polyuridylation-dependent mRNA catabolic process, exosome mediated process, and TRAMP-dependent tRNA surveillance pathway. Related genes in other species link the family to DEAD/DEAH box helicase function.