SLN1 — Neurospora crassa

Summary

NCU04615 (SLN1, NcSLN1) on Neurospora crassa chromosome 5 encodes a hybrid histidine kinase with osmosensor, peroxide sensor, and histidine phosphotransfer kinase activities, also possessing DNA-binding transcription factor activity and sequence-specific DNA binding. It is a membrane-associated protein localised to the plasma membrane, cytoplasm, and nucleus as part of a protein histidine kinase complex. SLN1 is associated with the histidyl-aspartyl phosphorelay, the high-osmolarity glycerol (HOG) response, MAPK cascade, response to singlet oxygen, regulation of conidium formation, filamentous growth, cell wall biogenesis, and cell size control. Phenotypic associations link SLN1 to altered osmotic stress resistance, cell cycle progression (including G1/S arrest and G2/M delay), decreased exponential growth, increased starvation resistance, and abnormal cytokinesis. Studies of related genes in other species connect the family to turgor pressure, oxidative stress response, and virulence.