NTF2 — Neurospora crassa

Summary

NTF2 (NCU04759) on Neurospora crassa chromosome 6 encodes a nuclear transport factor 2 family protein with nuclear import signal receptor activity and small GTPase binding. The protein localises to the nuclear pore central plug, nuclear membrane, nuclear envelope, cytoplasm, cytosol and nucleus, and is associated with protein import into the nucleus. NTF2 is associated with abnormal nuclear import, decreased nuclear export, arrested cell cycle progression in metaphase, abnormal chromosome segregation, decreased spore germination, abnormal sporulation, increased hyperosmotic stress resistance, decreased utilisation of carbon sources, abnormal mitochondrial morphology and genome maintenance, abnormal nuclear and endoplasmic reticulum morphology, decreased silencing, and increased mitotic recombination. The gene also shows connections to GSP1, GSP2, MOG1, NIC96, NSP1 and MAD2.