FPHA — Neurospora crassa

Summary

NCU04834 (FPHA, phy-1) on Neurospora crassa chromosome 6 encodes a phytochrome with histidine kinase activity, photoreceptor activity, peroxide sensor activity, and phosphorelay sensor kinase and response regulator activities. The protein contains GAF, PAS, histidine kinase, and CheY-like receiver domains. It is associated with detection of visible light, osmolarity sensing via a two-component system, regulation of conidium formation, sexual reproduction, ascospore formation, filamentous growth, fungal-type cell wall biogenesis, cellular responses to farnesol and reactive oxygen species, and the HOG pathway. The protein localises to the membrane, cytoplasm, cell tip, and cell division site. Related genes in other species link the family to virulence and pathogenicity traits, though these associations are not established for N. crassa.