ERG5 — Neurospora crassa

Summary

NCU05001, designated ERG5 (also known as ci-1) in Neurospora crassa, encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. The gene is associated with ergosterol, terpenoid, hormone, antibiotic, mycotoxin and secondary metabolism anabolism, as well as hypersensitivity and membrane localisation. ERG5 has been linked to increased fermentative growth and budding, decreased endocytosis, cytokinesis, meiosis, shmoo formation, mating response, nutrient uptake, and apoptosis, abnormal autophagy, plasma membrane morphology, cytoskeleton, mitochondrial distribution, peroxisomal morphology, telomere length, and cell cycle arrest at G2/M phase, absent micronucleophagy, vacuolar transport, protein secretion, and chemical compound accumulation, decreased colony size, increased cell death, and normal replicative lifespan. Related genes in other species link the family to potassium concentration and acid sensitivity.