RAD18 — Neurospora crassa

Summary

NCU05210, also known as RAD18, uvs-2, or RHP18, encodes a ubiquitin ligase with ssDNA-dependent ATPase activity and ssDNA binding, belonging to the Rad18 family with RING and SAP domains. In Neurospora crassa, this gene is associated with DNA damage tolerance, error-free translesion synthesis, nucleotide excision repair, and protein monoubiquitination, as well as meiosis, spermatogenesis, and pachytene. It is linked to responses to UV and UV-A, and localizes to chromatin and the nucleus. Phenotypic associations include altered cell cycle progression through G1/S and S phases, increased transposable element transposition, absent mitotic recombination, delayed meiotic recombination, arrested meiosis, and increased fermentative growth. Related genes in other species connect it to the Rad6-Rad18 complex and oxidative stress response.