CYC3 — Neurospora crassa

Summary

NCU05601, symbol CYC3 (cyt-2) in Neurospora crassa chromosome 6, encodes a holocytochrome-c synthase with metal-binding activity, placing it in the holocytochrome c/c1 synthase family. The gene product localises to the mitochondrial inner membrane and envelope lumen, and is associated with cytochrome c anabolism, ATP anabolism, oxidative phosphorylation, mitochondrial translation, and cell cycle progression. Phenotypic associations link CYC3 to decreased oxidative phosphorylation, absent anaerobic growth, altered mitochondrial morphology and genome maintenance, increased petite frequency, decreased sporulation efficiency, and abnormal cell cycle progression in G1 phase. The gene is also associated with increased hyperosmotic stress resistance and decreased UV resistance, as well as changes in biofilm formation, carbon source utilisation, and lipid particle morphology. Studies of related genes in other species support the family's role in mitochondrial respiration and cytochrome c maturation.