ASC1 — Neurospora crassa

Summary

NCU05810 (ASC1, also known as cpc-2) encodes a RACK1-like WD40-repeat protein that is a structural constituent of the ribosome and has signaling receptor activator activity. It is associated with the cytosolic small ribosomal subunit, ribosome hibernation, and negative regulation of cytoplasmic translation. The gene is linked to GCN2-mediated signaling, GPCR signaling, and response to amino acid starvation. ASC1 is associated with fruiting body formation, cleistothecium development, and positive regulation of autophagy. Phenotypic associations include abnormal pseudohyphal growth, premature apoptosis, increased adhesion, decreased meiosis, and sterility. The gene is also linked to cell cycle progression in G2 phase arrest and decreased ribophagy. Studies of related genes in other species connect the family to loss of pathogenicity and reduced virulence.