ubi — Neurospora crassa

Summary

NCU05995 (ubi) on Neurospora crassa chromosome 6 encodes a ubiquitin-domain protein that also has enzyme inhibitor activity and is a structural constituent of the ribosome, with a protein tag activity. The gene is associated with protein ubiquitination, modification-dependent proteolysis, the proteasomal pathway, and protein synthesis, as well as mitotic and meiotic cell cycle modulation, degradation of meiosis-specific transcripts, filamentous growth, phenotypic switching, cell wall assembly, cell morphogenesis, protein secretion, methylation, and cellular responses to stress and heat. It localises to the cytosolic ribosome, cytoplasm, nucleus, and plasmalemma. Phenotypic associations include abnormal mitophagy and micronucleophagy, absent oxidative stress resistance and alkaline pH resistance, premature apoptosis, decreased colony sectoring, delayed carbon source utilisation, altered cell cycle progression, and abnormal pheromone sensitivity and shmoo formation. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.