rco-1 — Neurospora crassa

Summary

NCU06205 (rco-1) on Neurospora crassa chromosome 3 encodes a protein with DNA-binding transcription repressor activity, transcription corepressor activity, mediator complex binding, histone deacetylase binding, and histone binding. It also binds GTP and phosphatidylinositol (3,5)-bisphosphate and is associated with ubiquitin ligase substrate adaptor activity. The protein contains WD40 repeats, localizing to the nucleus, cytoplasm, chromatin, and repressor complexes including Tup11/Tup12 and SCF complexes. Rco-1 is associated with carbon catabolite repression, circadian rhythm, cell-cell fusion and adhesion, filamentous growth, phenotypic switching, quorum sensing, regulation of glycogen and fatty acid metabolism, negative regulation of isoprenoid metabolism and dipeptide transport, HOG response, cellular response to copper, and development of symbiont in host. Related genes in other species are linked to reduced virulence.