DBP2 — Neurospora crassa

Summary

NCU06418 (DBP2) on Neurospora crassa chromosome 3 encodes a DEAD-box RNA helicase with RNA helicase activity, RNA binding, ATP hydrolase activity, and ATP binding. The gene is associated with RNA splicing, mRNA processing, ribosome biogenesis, and rRNA processing, and its product localizes to the nucleolus, cytosol, and nucleus. DBP2 is linked to fruiting body formation, sporulation efficiency, and sporulation, as well as vegetative growth, exponential phase growth, and carbon source utilization. It has been connected to cell cycle progression through G1/S and G2/M phase transitions, S phase and anaphase progression, mitotic recombination, chromosome segregation, and resistance to chemicals, gamma rays, and thermotolerance. Related genes in other species link the family to oxidative stress response.