chlE — Neurospora crassa

Summary

NCU06573 (chlE) on Neurospora crassa chromosome 4 encodes a carboxylic ester hydrolase of the carboxylesterase B family, possessing chlorogenate hydrolase, carboxylesterase and TAG hydrolase activities (EC 3.1.1.-). The gene is associated with cholesterol metabolism, lipolysis, lipid metabolism and iron transport, and its product is localised extracellularly. Studies of related genes in other species link the family to EC 3.1.1.42, EC 3.1.1.1 and EC 3.1.1.3, and to unaffected pathogenicity. The family also shows sequence similarity to genes from plants such as carnation, gerbera, tomato and lima bean, as well as from Fusarium pathogens.