DDB1 — Neurospora crassa

Summary

NCU06605 (DDB1, dim-8) on Neurospora crassa chromosome 4 encodes ddb-1, a protein containing WD40/YVTN repeat-like and beta-propeller domains characteristic of the RSE1/DDB1/CPSF1 family. The gene product possesses nucleic acid and DNA binding activities and is associated with the Cul4-RING E3 ubiquitin ligase complex, localizing to the nucleus, nucleolus, cytosol, and sites of DNA double-strand breaks. DDB1 is associated with circadian rhythm, chromatin silencing, DNA repair via transcription-coupled nucleotide excision repair and homologous recombination, protein ubiquitination and proteasomal degradation, degradation of meiosis-specific transcripts, methylation, chromosome division, and ectoderm development. Studies of related genes in fission yeast link the DDB1 family to the Ddb1-Wdr21 and Ddb1-Ckn1 complexes.