CRG1 — Neurospora crassa

Summary

NCU06616 (CRG1) in Neurospora crassa encodes an S-adenosylmethionine-dependent methyltransferase, placing it in the Diverse_substrate_MTase and Methyltransf_11 families. The gene is associated with methylation and flavonoid anabolism, and its product has been linked to the C7-OH methyltransferase CfoB. CRG1 is associated with abnormal flocculation, decreased oxidative phosphorylation, abnormal Golgi distribution, decreased budding, delayed mitophagy, decreased duration of cell cycle progression in G2 phase, increased necrotic cell death, arrested meiosis, normal cell size, abnormal plasma membrane morphology, absent budding, increased critical cell size at start, abnormal spore wall formation, absent RNA modification, normal replicative lifespan, decreased protein/peptide distribution, normal heat sensitivity, decreased bipolar budding pattern, decreased chitin deposition, decreased nutrient uptake, delayed cell cycle progression through the G2/M phase transition, increased cell death, decreased utilization of phosphorus source, decreased rate of nutrient uptake, abnormal cytokinesis, increased silencing, absent chemical compound accumulation, decreased X-ray resistance, and decreased vacuolar transport. Studies of related genes in other species link the family to increased transposable element transposition.