CYC8 — Neurospora crassa

Summary

NCU06842 (CYC8, also known as rcm-1 or SSN6) in Neurospora crassa encodes a transcriptional corepressor with chromatin DNA binding and RNA polymerase II cis-regulatory region sequence-specific DNA binding activities, belonging to the Corepressor-Demethylase and TPR repeat families. The gene is associated with carbon catabolite repression, negative regulation of transcription by RNA polymerase II, and regulation of glycogen metabolism. Its product localises to the nucleus, cytoplasm, chromatin, and transcription repressor complex. Studies of related genes in other species link the family to reduced virulence and oxidative stress response, though these associations are not established for N. crassa itself.