lgd1 — Neurospora crassa

Summary

NCU07064 (lgd1) on Neurospora crassa chromosome 6 encodes L-galactonate dehydratase, a member of the mandelate racemase/muconate lactonizing enzyme family with enolase-like domains. The enzyme exhibits L-fuconate hydratase and carbonic anhydrase activities, requires magnesium binding, and has hydro-lyase activity. This gene is associated with amino acid breakdown, D-galacturonate breakdown, carbohydrate breakdown, and fermentation. Related genes in other species link the family to L-fuconate dehydratase activity (EC 4.2.1.146) and mandelate racemase N-terminal domains, with sequence similarity to proteins from Verticillium dahliae and Fusarium oxysporum.