MBP1 — Neurospora crassa

Summary

NCU07246, designated MBP1 in Neurospora crassa and located on chromosome 5, encodes a protein containing SWI6-like, KilA/APSES_HTH and ankyrin repeat domains. The protein exhibits both transcription repressor and activator activities specific to RNA polymerase II. MBP1 is associated with the regulation of asexual reproduction, sporulation, conidia formation, melanin anabolism, protein secretion, fermentation, and steroid, lipid and amino acid metabolism. It localises to the nucleus, cytoplasm, chromatin and the SBF/MBF complexes. The gene is linked to cell cycle progression, particularly the G1/S phase transition, meiotic cell cycle modulation, mating efficiency, and responses to pheromone. Associations with germination rate, vegetative growth, chronological lifespan, and gamma ray resistance have also been noted. Studies of related genes in other species connect the family to cell cycle control through START and budding.