CWC25 — Neurospora crassa
Summary
NCU07296 (CWC25, cot-1) on Neurospora crassa chromosome 4 encodes a protein serine/threonine kinase with protein kinase activity (EC 2.7.11.1) and identical protein binding, containing a Rho-assoc_Ser/Thr_Kinase domain and AGC-kinase_C domain. The gene is associated with positive regulation of filamentous growth, upregulation of nuclear migration during mitotic telophase, mitotic spindle elongation, actomyosin contractile ring contraction, and exocytosis. It is linked to the Sid2-Mob1 complex, the actomyosin contractile ring, hyphal tips, and the cytoskeleton. Additional associations include regulation of growth, protein secretion, cellular salinity response, mitotic cytokinesis checkpoint, and DNA-mediated transformation. Studies of related genes in other species link the family to loss of pathogenicity.
Annotations
- Chromosome
- 4
- Related genes
- COT-1, CWC25
- GO terms
- Hypersensitivity, protein synthesis, Cell Growth, Cytokinesis, PH Reduction, DNA mediated transformation, mating projection assembly, Anaphase
- Publications
- PMID:16506053, PMID:9680960, PMID:32503980, PMID:11254137, PMID:9819052, PMID:12456722, PMID:11259593, PMID:17419877
- Traits
- loss of pathogenicity