CBHA — Neurospora crassa

Summary

NCU07340, symbol CBHA (cbh-1) in Neurospora crassa on chromosome 4, encodes a cellulose 1,4-beta-cellobiosidase (EC 3.2.1.91) belonging to the Glyco_hydro_7 family, with cellulose-binding and ConA-like domains. The enzyme is secreted and associated with cellulose and glucan breakdown, as well as regulation of cellulose breakdown, carbon catabolite repression, fermentation, protein secretion, and hypersensitivity. Studies of related genes in other species link the family to cellulose hydrolysis and apoplastic effector functions in plant pathogens such as Verticillium dahliae and Fusarium oxysporum.