mdk-1 — Neurospora crassa

Summary

NCU07580 (mdk-1) on Neurospora crassa chromosome 3 encodes a cyclin-dependent protein kinase with serine/threonine kinase activity, ATP binding, RNA polymerase II core binding, and histone binding. It is a member of the CDK and protein kinase domain families. The gene is associated with positive regulation of anabolism and protein breakdown, upregulation of mitotic cell cycle DNA replication and phase transition, downregulation of mitotic spindle elongation and spindle microtubule attachment, and regulation of meiotic DNA double-strand break formation and linear element maturation. It is linked to responses to mitotic DNA integrity and G2 DNA damage checkpoint signaling, negative regulation of primary cell septum biogenesis and anaphase-promoting complex-dependent catabolism, and regulation of cellular response to glucose starvation. The product localizes to CDK-cyclin complexes, spindle pole bodies, meiotic and mitotic spindles, and telomeric chromosome regions. Studies of related genes in other species link the family to phosphorus concentration, germination rate, and oxidative stress response.