HELA — Neurospora crassa

Summary

NCU07670, designated HELA (also cyt-19) on Neurospora crassa chromosome 4, encodes a DEAD/DEAH-box RNA helicase with ATP hydrolase, RNA helicase, RNA strand annealing, and G-quadruplex binding activities. The gene is associated with mitochondrial RNA processing, including group I and group II intron splicing, mRNA processing, rRNA processing, mitochondrial translation initiation and elongation, and RNA folding and positioning. It is also linked to regulation of translation and maturation of LSU-rRNA from the tricistronic transcript. The encoded protein localises to mitochondria, the mitochondrial lumen, the mitochondrial ribosome, and the nucleolus. Related genes in other species include the ATP-dependent RNA helicase HAS1.