arg-2 — Neurospora crassa

Summary

NCU07732 (arg-2) on Neurospora crassa chromosome 4 encodes a carbamoyl-phosphate synthase (glutamine-hydrolyzing) enzyme (EC 6.3.5.5), possessing glutaminase activity and ATP binding, and belongs to the CPSase_GATase1 domain family. This gene is associated with arginine and ornithine anabolism, de novo pyrimidine base anabolism, glutamine metabolism, and amino acid anabolism. It is also linked to translational attenuation, regulation of translation, translation elongation and initiation, protein synthesis, DNA metabolism, methylation, digestion, and response to amino acids. The encoded product localizes to the carbamoyl-phosphate synthase complex, mitochondrial lumen, and cytoplasm. Studies of related genes in other species link the family to reduced virulence.