MDMB — Neurospora crassa

Summary

NCU07824 (MDMB, MDM10) in Neurospora crassa encodes a protein. The gene is associated with mitochondrial migration, distribution, and protein import, as well as TOM complex assembly and phospholipid transport. It localises to the SAM complex and the mitochore. Phenotypic associations include decreased oxidative phosphorylation, absent respiratory metabolism and thermotolerance, increased apoptosis and mutation frequency, arrested cell cycle progression, abnormal colony colour and shape, decreased colony size and lifespan, and absent spore germination. The gene is also linked to abnormal nuclear transport and endocytosis, and altered critical cell size at the G1 checkpoint. Studies of related genes in other species connect the family to oxidative stress response and increased telomere length.