ATRR — Neurospora crassa

Summary

NCU08044, designated ATRR, is located on chromosome 4 of Neurospora crassa and encodes a short-chain dehydrogenase/reductase (SDR) family protein with acylglycerone-phosphate reductase (NADP+) activity, also annotated for oxidoreductase activity acting on CH-OH group donors and phosphopantetheine binding. The gene is associated with triglyceride breakdown, sterol and ergosterol anabolism, phosphatidic acid anabolism, and sterol homeostasis. Its product localises to the adiposome, mitochondrial outer membrane, fungal-type vacuole membrane, Golgi, endoplasmic reticulum, and cytosol. ATRR is linked to numerous phenotypes including decreased acquired thermotolerance, decreased replicative lifespan, decreased desiccation resistance, increased telomere length, increased mutation frequency, decreased UV resistance, decreased oxidative stress resistance, decreased vegetative growth rate, and decreased competitive fitness. Studies of related genes in other species connect the family to transposable element transposition and chronological lifespan.