HEM15 — Neurospora crassa

Summary

NCU08291 (HEM15) on Neurospora crassa chromosome 4 encodes a ferrochelatase (protoheme ferrolyase activity, EC 4.98.1.1). The protein contains ferrochelatase N-terminal, C-terminal and active-site domains and binds a 2Fe-2S cluster. HEM15 is associated with heme anabolism and localises to the mitochondrial inner membrane, mitochondria, cytosol and nucleus. The gene is linked to homologous recombination, methylation, DNA repair, cell cycle progression (S and M phase arrest, increased S phase duration), cytokinesis, mitophagy, mitochondrial genome maintenance and transport, respiratory metabolism, polyploidy, budding index, prion formation and loss, desiccation resistance, UV resistance, petite-negative and petite phenotypes, viability, vegetative growth, nitrogen source utilisation, and protein/peptide accumulation, distribution and modification.