rco-1 — Neurospora crassa

Summary

NCU08485 (rco-1) on Neurospora crassa chromosome 2 encodes a WD40 repeat-containing protein with DNA-binding transcription repressor activity, transcription corepressor activity, mediator complex binding, histone deacetylase binding, dynein complex binding, microtubule plus-end binding, histone binding, ubiquitin ligase substrate adaptor activity, and GTP binding. The gene is associated with carbon catabolite repression, circadian rhythm, cell-cell fusion, regulation of glycogen and fatty acid metabolism, negative regulation of isoprenoid metabolism, quorum sensing, filamentous growth, HOG response, microtubule organizing center organization, vesicle transport along microtubules, and mitigation of host defenses. It localizes to transcription repressor complexes, the SCF complex, microtubule-associated complexes, kinetochore, chromatin, and nuclear envelope. Studies of related genes in other species link the family to reduced virulence.