PER1 — Neurospora crassa

Summary

NCU08609, designated NcPER1 (also known as PERA or PGA3) on Neurospora crassa chromosome 1, encodes a Per1-like family protein with esterase activity. The gene is associated with cellular manganese ion homeostasis, GPI anchor anabolism, DNA damage response, cell division and cell cycle processes, and localises to the fungal-type vacuole membrane and ER membrane. Phenotypic associations link NcPER1 to abnormal autophagy, mitophagy, pexophagy, micronucleophagy and reticulophagy, as well as absent or altered vacuolar transport, protein secretion, budding and small molecule transport. The gene is also associated with increased vegetative growth, sporulation efficiency and respiratory growth, decreased nutrient uptake and freeze-thaw resistance, arrested cell cycle progression, and abnormal meiosis, Golgi distribution and subcellular morphology. Related genes in other species link the family to abnormal protein transport, cell shape and stress resistance.