bd — Neurospora crassa

Summary

NCU08823 (bd) on Neurospora crassa chromosome 4 encodes a small GTPase of the Ras-type family, with GTP, GDP, CTP and UTP binding activities, GTPase activity, and protein ser/thr kinase activator activity. The gene is associated with Ras protein signal transduction, positive regulation of the pheromone response MAPK cascade, regulation of conjugation with cellular fusion, mating type switching, conidium formation, spore germination, cell shape regulation, and cell polarization. It localizes to the plasma membrane, cytoplasm, nucleus, division septum, and mating projection actin fusion focus. Phenotypic associations include altered vacuolar transport, bipolar budding pattern, redox state, mating type switching, entry into G0, osmotic and oxidative stress resistance, nuclear export, pheromone production, protein transport, cell cycle progression, prion inheritance, flocculation, and transposable element transposition. Related genes in other species are linked to protein content and oxidative stress response.