DBF2 — Neurospora crassa

Summary

NCU09071 (DBF2) in Neurospora crassa encodes a serine/threonine protein kinase of the AGC family, with ATP-binding and identical protein-binding activities. The gene is associated with regulation of FSM assembly, actomyosin organization, lipid raft organization, glycogen metabolism, and the mitotic cytokinesis checkpoint. It is linked to positive regulation of primary cell septum biogenesis, negative regulation of protein localization to the medial cortex, and maintenance of protein location in the cell cortex. Phenotypic associations include abnormal cell cycle progression, absent septum formation, delayed chromosome segregation, decreased lifespan, and altered redox state. The product localizes to the spindle, actomyosin contractile ring, hyphal tip, and spindle pole body. Related genes in other species connect it to the Sid2-Mob1 complex.