nuc-1 — Neurospora crassa

Summary

NCU09315, symbol nuc-1, on Neurospora crassa chromosome 1, encodes a basic helix-loop-helix (bHLH) transcription factor with sequence-specific DNA-binding and protein dimerization activity, belonging to the MASH1/Ascl1a-like family. This gene is associated with the regulation of phosphate transport and phosphorus metabolism, as well as broader processes including regulation of transcription by RNA polymerase II, signal transduction, protein acetylation, membrane biogenesis, secretion, digestion, cell growth, and chromatin modeling. It is linked to organelle assembly, phospholipid anabolism, and lipid metabolism. The encoded product localizes to the RNA polymerase II transcription regulator complex. Studies of related genes in other species connect the family to phosphate homeostasis, though this is not established for nuc-1 itself.