aac — Neurospora crassa

Summary

NCU09477 (symbol aac, also known as AAC1, ANC1, NcAAC1, NcANC1, NcPET9, AAC3, NcAAC3, PET9) on Neurospora crassa chromosome 2 encodes an ADP/ATP carrier protein of the mitochondrial carrier family (ADT_euk_type, Mit_carrier). The gene product is associated with ATP/ADP exchange, aspartate:glutamate antiporter activity, 2-oxoglutarate transporter activity, thiamin permease activity, and dicarboxylic acid transmembrane transporter activity. It localises to the mitochondrial inner membrane and the MPTP complex, and is linked to nucleotide transport, heme transport, mitochondrial ADP/ATP transmembrane transport, regulation of mitochondrial membrane permeability, anaerobic respiration, the malate-aspartate shuttle, mitochondrial protein import, and mitochondrial biogenesis. Phenotypic associations include delayed respiratory growth, increased nitrogen utilisation, decreased oxidative phosphorylation, premature apoptosis, increased necrotic cell death, decreased lifespan, abnormal colony colour, and increased hydrostatic pressure resistance. Related genes in other species are linked to reduced virulence.