SSA1 — Neurospora crassa

Summary

NcSSA1 (SSA1) on Neurospora crassa chromosome 2 encodes a member of the Hsp70 family of heat shock proteins, possessing ATP hydrolase activity, ATP binding, heat shock protein binding, and protein folding chaperone functions, and also acting as a transcriptional co-regulator. The gene is associated with carbon catabolite repression, mitochondrial protein import and biogenesis, protein refolding and modification, pheromone response, cellular osmotic response, cellulose breakdown, and regulation of gene expression. Its product localises to the cytoplasm, cytosol, nucleus, plasmalemma, fungal-type cell wall, and extracellular. Phenotypic associations include increased thermotolerance, altered cell cycle progression, abnormal pheromone sensitivity and recovery, premature apoptosis, increased prion inheritance, decreased nuclear import rate, and increased nutrient uptake. Related genes in other species link the family to oxidative stress response and amino acid, protein, and phosphate content.