OPI — Neurospora crassa

Summary

NCU09686 (NcOPI, also known as ccg-8) on Neurospora crassa chromosome 5 encodes a transcription corepressor belonging to the TF_Opi1 family. The gene is associated with the regulation of transcription by RNA polymerase II, ribosome biogenesis, and homeostasis. It has been linked to fatty acid oxidation, phospholipid anabolism, ergosterol anabolism, and the endoplasmic reticulum unfolded protein response (erUPR). The encoded protein localises to both the ER and nucleus. Related genes in other species are linked to clock-controlled protein 8 and to pathogens such as Verticillium dahliae and Fusarium oxysporum, though these associations are not established for N. crassa.