PMT3 — Neurospora crassa

Summary

NCU09813 (PMT3) on Neurospora crassa chromosome 1 encodes a protein containing Rad60/SUMO-like and ubiquitin-like domains, with E3 protein ligase binding and protein tag molecular functions. The gene is associated with sumoylation, telomere maintenance, stalled replication fork localization to the nuclear periphery, mitotic recombination-dependent replication fork processing, NADPH regeneration, fermentation, and protein synthesis. It localizes to the nucleus, mitotic spindle pole body, linear element, and septin ring. Phenotypic associations include delayed growth, altered cell cycle progression through G1/S and anaphase, delayed chromosome segregation, decreased meiotic recombination, meiotic arrest, sterility, abnormal colony shape, decreased radiation resistance, and increased aneuploidy. Studies of related genes in other species link the family to reduced virulence, increased fermentative growth, and altered carbon source utilization.