DCW1 — Neurospora crassa

Summary

NcDCW1 (NCU09937) on Neurospora crassa chromosome 4 encodes a protein with endo-alpha-D-mannosidase activity (EC 3.2.1.101) belonging to the GH76 family, with the protein product gh76-5. This gene is associated with fungal-type cell wall biogenesis and organization, septum digestion after cytokinesis, and regulation of filamentous growth. It is also linked to budding cell bud growth, carbohydrate breakdown, and cellular response to xenobiotic stimulus. The encoded protein localizes to the external side of the plasma membrane, fungal-type cell wall, ER membrane, and extracellular region. Phenotypic associations include absent or decreased budding, absent filamentous growth, sterile mating response, abnormal Golgi distribution, altered endocytosis and pexophagy, decreased chitin deposition, and increased alkaline pH resistance and starvation resistance.