hgt-1 — Neurospora crassa

Summary

NCU10021 (hgt-1) on Neurospora crassa chromosome 7 encodes a member of the MFS sugar transporter family with high-affinity glucose:proton symporter activity, glucose, galactose and gluconate transmembrane transporter activity and D-glucose binding. The gene is associated with carbon catabolite repression, response to glucose, glucose import and signalling, galactose and gluconate import, monocarboxylic acid metabolism, ethanol fermentation, the TCA cycle, carbohydrate transport, fermentation, meiotic cell cycle and signal transduction. Its product localises to the plasma membrane, cell tip, cell division site, fungal-type vacuole and vacuole lumen. Studies of related genes in other species link the family to unaffected pathogenicity, though this has not been established in N. crassa.