ELFA — Neurospora crassa

Summary

NCU10521 (ELFA, gst-4) on Neurospora crassa chromosome 7 encodes a protein with transferase activity, belonging to the EF-GSTs family and containing thioredoxin-like and glutathione S-transferase domains. The gene is associated with activation of oxidative metabolism, plasma membrane repair, cellular respiration, translation elongation, membrane transport, terpenoid anabolism, and homeostasis, and its product localizes to both cytoplasm and nucleus. Phenotypic associations include absent innate thermotolerance, abnormal peroxisomal morphology, decreased peroxisomal transport, absent and decreased carbon source utilization, decreased respiratory growth, decreased heat sensitivity, increased and decreased chronological lifespan, decreased chromosome/plasmid maintenance, decreased oxidative stress resistance, increased competitive fitness, abnormal vacuolar morphology, haploid insufficiency, decreased vegetative growth, and both increased and decreased chemical resistance. Studies of related genes in other species link the family to oxidative stress response and decreased starvation and toxin resistance.