CLM2 — Neurospora crassa

Summary

NCU11306 (CLM2) in Neurospora crassa encodes a cytochrome P450, with oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen, heme binding, iron binding, and monooxygenase activity. This gene is associated with ergosterol and sterol anabolism, ceramide and phospholipid anabolism, antibiotic anabolism, sterol homeostasis, and membrane localisation. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; abnormal cell cycle progression through G2/M phase and S phase; increased cell death; decreased hyperosmotic stress resistance, ionizing radiation resistance, and invasive growth; vegetative growth arrest; increased fermentative metabolism; and abnormal plasma membrane morphology, endoplasmic reticulum distribution, and Golgi distribution. Studies of related genes in other species link the family to ergosterol biosynthesis.