PHOC — Neurospora crassa

Summary

NCU11426 (PHOC, nuc-2) on Neurospora crassa chromosome 2 encodes a protein with an SPX domain, a peptidase A2 catalytic domain, and ankyrin repeats, and is annotated with phosphoric diester hydrolase, protein-cysteine S-palmitoyltransferase, and aspartic endopeptidase activities. The gene is associated with regulation of phosphate transport, Pi homeostasis, phosphorus metabolism, protein membrane targeting, digestion, phospholipid anabolism, proteolysis, signal transduction, DNA repair, and meiosis. It localizes to early endosome, fungal-type vacuole, Golgi, and ER membranes. Phenotypic associations include decreased nutrient uptake and transport, altered spore germination, cell cycle delays, increased stress resistance (alkaline pH, ionic, hyperosmotic, starvation), increased autophagy and mitophagy, and altered growth rates. Related genes in other species link the family to cyclin-dependent kinase inhibition and phosphate signaling.