AIF1 — Neurospora crassa

Summary

NcAIF1 (NCU12058) on Neurospora crassa chromosome 7 encodes a protein with a FAD/NAD-binding domain and electron-transferring-flavoprotein dehydrogenase activity, localizing to the mitochondrial membrane and cytoplasm. The gene is associated with apoptotic mitochondrial changes, negative regulation of ferroptosis, upregulation of apoptosis, cell death, autophagy, mating type switching, meiosis, and mating. Phenotypic associations include increased necrotic cell death, abnormal spindle and cytoskeleton morphology, decreased cold sensitivity, altered fermentative and respiratory metabolism, decreased mutation frequency, increased filamentous growth, and abnormal colony appearance. Studies of related genes in other species link the family to increased oxidative stress resistance and viability.