ATP6 — Neurospora crassa

Summary

NCU16026 (NcATP6, ATP6) on the Neurospora crassa mitochondrial chromosome encodes F-ATPase protein 6, a component of the ATP synthase F0 subunit that also contains a LAGLIDADG homing endonuclease domain. The gene product is associated with proton transporter activity, proton-transporting ATP synthase activity, ubiquinone binding and reductase activities, and NADH dehydrogenase activity. It localises to the mitochondrial inner membrane, the F1-F0 complex and respiratory chain complex I. Associations include ATP synthesis coupled electron transport, proton motive force-driven ATP synthesis, mitochondrial transcription, RNA splicing, intron homing and spore germination. Phenotypic associations link the gene to decreased oxidative phosphorylation, absent anaerobic growth, altered respiratory metabolism, increased petite mutation frequency, abnormal mitochondrial genome maintenance, decreased survival in stationary phase, altered cell cycle progression, abnormal sporulation and biofilm formation.