ATP9 — Neurospora crassa

Summary

NCU16027 (NcATP9, also known as OLI1) on the Neurospora crassa mitochondrial chromosome encodes the ATP synthase F0 subunit 9 (atp-9), a proteolipid component of the proton-transporting two-sector ATPase complex. The gene product possesses proton transporter activity and proton-transporting ATP synthase activity, and is localised to the mitochondrial inner membrane. NcATP9 is associated with proton motive force-driven ATP synthesis, oxidative phosphorylation, and spore germination. The gene has been linked to numerous phenotypes including decreased respiratory metabolism, increased mitophagy, decreased apoptosis, abnormal mitochondrial genome maintenance, increased filamentous growth, absent sporulation, decreased survival in stationary phase, and increased biofilm formation. It is also associated with altered chitin deposition, decreased alkaline pH resistance, and absent anaerobic growth. Studies of related genes in other species connect the family to mitochondrial ATP6 and MDM38 functions.