HAP5 — Neurospora crassa

Summary

NCU00116 (HAP5, aab-1) on Neurospora crassa chromosome 3 encodes a histone-fold domain-containing protein with DNA-binding transcription activator activity specific to RNA polymerase II and protein heterodimerization activity. The gene is associated with regulation of transcription by RNA polymerase II, siRNA-mediated silent mating type cassette region heterochromatin formation, and regulation of aerobic respiration. It has been linked to numerous phenotypes including abnormal respiratory metabolism, increased survival rate in stationary phase, increased osmotic stress resistance, abnormal chromosome segregation, increased mitophagy, delayed G1 phase cell cycle progression, arrested G2/M phase transition, increased apoptosis, abnormal nuclear position, and increased fermentative metabolism. The gene product localizes to the nucleus, chromatin, centric heterochromatin, and cytoplasm. Studies of related genes in other species connect the CCAAT-binding factor complex family to biofilm formation and stress resistance.