SET2 — Neurospora crassa

Summary

NCU00269 (SET2, set-2) on Neurospora crassa chromosome 3 encodes a histone H3K36 methylase with dimethylase and trimethylase activities, belonging to the SETD2/Set2_SET domain family and also containing RNA-binding domains. The gene is associated with suppression of meiotic recombination, DNA replication licensing, transcription elongation and termination, co-transcriptional chromatin reassembly, sno(s)RNA transcription, negative regulation of antisense RNA transcription, ascospore formation, and chromatin remodeling. It localizes to the nucleus, chromatin, and cytosol. Phenotypic associations include increased rates of RNA accumulation, small molecule transport, transposable element transposition, sporulation, nutrient uptake, carbon source utilization, and polyploidy, along with abnormal pheromone production and mating response, decreased spore germination, delayed cell cycle progression through G2/M and G1/S transitions, delayed chromosome segregation, and absent alkaline pH resistance and fermentative growth. Related genes in other species link SET2 to acid sensitivity.