TOM22 — Neurospora crassa

Summary

NCU00431, designated TOM22 in Neurospora crassa, encodes a fungal Tom22 family protein, a component of the mitochondrial outer membrane translocase (TOM) complex. The gene product exhibits ATP hydrolase activity and is associated with mitochondrial protein import, including matrix protein import and intracellular protein transport. Localisation evidence places it in the mitochondrial outer membrane translocase complex. Phenotypic associations link TOM22 to normal mitochondrial transport, decreased oxidative phosphorylation, abnormal respiratory metabolism, increased mitochondrial genome maintenance, absent spore germination, absent filamentous growth, delayed cell cycle progression, increased cell death, abnormal redox state, increased acid pH resistance, and petite-negative status. The gene is also associated with absent peroxisomal transport and morphology, abnormal endocytosis and vacuolar transport, decreased necrotic cell death, and altered prion loss.